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发布时间：2025-09-11 19:27:05 来源：都市天下脉观察 作者：焦点

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How to lower your Alzheimer’s risk, according to Dr. Daniel Amen

The acclaimed psychiatrist and brain disorder specialist explains how everyday choices — from diet and exercise to blood flow — can either protect or accelerate cognitive decline.

Researchers have uncovered a new factor that could contribute to Alzheimer’s disease development.

A study by Harvard Medical School has identified low lithium levels in the brain as a possible trigger for the common dementia.

Lithium is known to have many functions in the brain, including balancing mood-regulating chemicals, protecting neurons and managing emotional processing. It has also been used to treat bipolar disorder and depression.

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Now, new findings show that the metal could be a "missing link" in Alzheimer’s risk, according to a Harvard press release.

The researchers tested lithium’s effects in mice, as well as human brain tissue and blood samples.

In a mouse model of Alzheimer's disease, lithium deficiency, right, dramatically increased amyloid beta deposits in the brain compared with mice that had normal physiological levels of lithium, left. Bottom row: The same was true for the Alzheimer’s neurofibrillary tangle protein tau. (Yankner Lab)

The human brain samples were obtained in partnership with the Rush Memory and Aging Project in Chicago, which maintains post-mortem brain tissue from thousands of donors. 

The samples represented the full spectrum of cognitive health, ranging from no sign of disease to mild cognitive impairment to advanced Alzheimer’s, the release stated.

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They discovered that lithium levels became lower as signs of the disease increased, showing as "greatly diminished" in advanced Alzheimer’s patients.

"It’s the first time anyone’s shown that lithium exists at a natural level that’s biologically meaningful without giving it as a drug."

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